I am interested in the functions of RNA molecules. Contrary to the linear messenger RNA molecules depicted in Biology textbooks, RNA molecules inside cells are highly structured and bound by proteins. This have important consequences for most cellular functions, including transcription, RNA processing, RNA export, RNA localization, translation and RNA stability. However, RNA structure and the RNA-protein interactome remains largely unmapped and filling in this gap in our knowledge will be an important step forward in our understanding cellular function. The current aim of my Laboratory is therefore to improve the methods for RNA structure probing and make RNA structure probing global by applying modern sequencing technologies.
One consequence of RNA structure and RNA-protein interactions is that the accessibility of the RNAs for endogenous regulatory RNAs and for RNA-targeted drugs is restricted. In COAT, we collaborate with the other academic partners and Santaris to determine the consequences of RNA accessibility on the specificity and potency RNA drugs such as antisense oligonucleotides (ASOs) and siRNAs.
I did my undergraduate a the Technical University of Copenhagen and went on to do a Master and a PhD in Human Biology at the Department of Molecular Pathology, University of Copenhagen. I then joined the Department of Biology as a postdoc, before becoming assistant professor and I am now groupleader and associate professor in the Section for Computational and RNA Biology at the Department of Biology.
COAT projects with involvement of the Vinther Lab:
- RNA structure probing (with Krogh, Pedersen and Salama/Haussler groups)
- Oligonucleotide protein binding (with Santaris)
- Specificity of oligonucleotides (with Santaris)
- LNA-stop-Seq (with Santaris)
Vinther Lab members associated with COAT: