My group has a long-term interest in RNA molecular biology, and our focus is on post-transcriptional events such as RNA localization, RNA stability, and translational control, with an emphasis on the role of cytoplasmic RNA-binding proteins expressed during fetal life and oncogenesis. We employ biochemical, cell-biological and organism approaches to address these issues, combined with an increasing use of high-throughput technologies.
The role of our group in COAT is to establish the UV-crosslinking & immunoprecipitation technology (CLIP) in order to study direct RNA-protein interactions; and we are mainly responsible for work package 3. Moreover, we are also contributing to various aspects in work package 6, such as experimental validation of predicted higher-order RNA structures.
Members in my group that are attached to COAT:
- Sidsel Kramshøj Adolph
- Heidi Hansen