Results

COAT started in 2011, so far the following results have been presented to the scientific community:

Peer-reviewed papers

  • Kielpinski, L.J., and Vinther, J. (2014). Massive parallel-sequencing-based hydroxyl radical probing of RNA accessibility. Nucleic Acids Res. (link)
  • Pedersen, L, Hagedorn PH, Lindholm MW, Lindow M. A Kinetic model explains why lower-affinity enzyme-recruiting oligonucleotides can be more potent. Molecular Therapy Nucleic Acids 2014, Molecular Therapy Nucleic Acids (2014) 3, e149 (link)
  • Peter H Hagedorn, Victor Yakimov, Søren Ottosen, Susanne Kammler, Niels F Nielsen, Anja M Høg, Maj Hedtjärn, Michael Meldgaard, Marianne R Møller, Henrik Ørum, Troels Koch, and Morten Lindow. Hepatotoxic Potential of Therapeutic Oligonucleotides Can Be Predicted from Their Sequence and Modification Pattern. Nucleic Acid Therapeutics 2013, 23:302-310 (link)
  • JL Rukov, R Wilentzik, I Jaffe, J Vinther, N Shomron. Pharmaco-miR: Linking microRNAs and drug effects. Briefings in Bioinformatics 2013, In press (link)
  • Simon H Rasmussen, Anders Jacobsen, Anders Krogh. cWords – systematic microRNA regulatory motif discovery from mRNA expression data Silence 2013, 4:2 (link)
  • Lindow, M. et al. Assessing unintended hybridization-induced biological effects of oligonucleotides. Nature Biotechnology 2012, 30, 920–923 (link)

Posters and talks

RNA Society Meeting 2014

  • Lukasz Kielpinski, talk and poster:  Massive parallel sequencing based hydroxyl radical probing of RNA accessibility (HRF-Seq) using Fenton chemistry and synchrotron irradiation [poster]

DIA/FDA Oligonucleotide-based therapeutics (2013)

  • Morten Lindow, talk:  Measurement and Prediction of Hybridization-induced Off-target Effects of Oligonucleotide Drug Candidates. [slides]

Oligonucleotide Therapeutics Society, 9th annual meeting (2013) 

  • Peter Hagedorn, talk: Hepatotoxic Potential of Therapeutic Oligonucleotides Can Be Predicted From Their Sequence and Modification Pattern

Cold Spring Harbour RNA and Oligonucleotide Therapeutics (2013)

  • Lykke Pedersen, Poster: A kinetic model of enzyme recruiting oligonucleotides predicts an optimal affinity and thus explains why shorter and less affine oligonucleotides may be more potent
  • Peter Hagedorn, Poster: Hepatotoxic Potential of Therapeutic Oligonucleotides Can Be Predicted from Their Sequence and Modification Pattern
  • Morten Lindow, Talk: A model and data driven approach to oligonucleotide drug discovery

RNA Meeting 2013

Oligonucleotide Therapeutics Society, 8th annual meeting (2012) (conference website)

Oligonucleotide Therapeutics Society, 7th annual meeting (2011)