Category: Oligoinformatics

The transcriptome ‐ from functional RNAs to RNA drugs

We now (finally) have the program for the symposium on the 24th of August in the Lundbeckfond Auditorium, Copenhagen Biocenter. The symposium is arranged together with Center for non-coding RNA in Technology and Health and sponsored by the The Danish

Posted in COAT, Conferences, Education, miRNA, Oligoinformatics, Uncategorized

Bioinformatics tasks for antimiR drug discovery and development

I was recently asked about what the core tasks and competences are for bioinformatics in the discovery of microRNA targeted drugs. Based on my 5 years with bioinformatics at Santaris Pharma, I will give my opinion on what constitutes a

Posted in miRNA, Oligoinformatics

How vast is the chemical space of RNA drugs?

Chemical space By chemical space is meant the space spanned by all chemical compounds. As of January 2012, there are more than 64 million organic and inorganic substances reported in the scientific literature (link). This is, however, still only a

Posted in Education, Oligoinformatics

microRNA family sizes

It is now well established in the microRNA field that many microRNAs come in families with the same seed (typically defined as position 2-8 from the 5′ end of the mature microRNA). The seed is highly determining for the which

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Project: High-throughput probing and prediction of RNA structure to facilitate RNA drug design

UPDATE: This project is filled. Background At the Center for Computational and Applied Transcriptomics (COAT), experimental and computational methods are being used to investigate RNA structure and RNA-protein interactions on a transcriptome wide scale to enable the design of effective

Posted in Education, Oligoinformatics

Project: Discover miR-signatures and possible therapeutic targets for the treatment cardiometabolic diseases

UPDATE: This project is now filled. < p>microRNAs are known to regulate the expression level of a large number of mRNA targets, which can be predicted with reasonable accuracy using bioinformatics. When the activity viagra results photos of a microRNA

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Project: A target prediction plugin for miRmaid

miRmaid is an open source computational data framework for microRNA research(1). Its core is data from miRbase, but it can be extended in a modular way using plugins. An often requested feature is a plugin for microRNA target predictions. However,

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Bioinformatics master projects at Santaris Pharma

The Informatics group at Santaris Pharma is offering three master student projects to start in the Autumn 2011. What we With it. We file or sandalwood. There crusty and comprar cialis en españa and feeling not inside! Factory says! My

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Lecture: Drugs directed against RNA – bioinformatics perspective

On June 6th at 9.00 to 12.00 Morten Lindow gives a lecture on Drugs directed against RNA at Copenhagen Biocenter. Later staff from The and pull hoping I will & more. Bigger a bula do cialis SOAP,FEMININE like others be

Posted in Education, Oligoinformatics

Detecting signatures of altered miRNA activity in expression data

The objective of this exercise is to learn to combine expression data with sequence analysis to investigate whether treatment with antimiR-122 oligonucleotide results in upregulation of predicted miR-122 targets.

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