Leveraging transcriptomics for antisense oligonucleotide drug discovery

Advances in massive parallel sequencing provide an unprecedented ability to survey the transcriptome. Sequencing-based approaches allow studying globally not only RNA abundance and splice isoforms, but also structure and accessibility, binding of proteins, as well as rates of turnover—all of which are major factors influencing potency and efficacy of antisense oligonucleotides targeting RNA. It is our view that many long-standing challenges in the therapeutic application of antisense oligonucleotides may be resolved by mapping out

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the druggable transcriptome.

We are currently reviewing recent studies (besides our own) applying transcriptomics for investigating therapeutic oligonucleotides. Do you work in this field and have soon-to-be-published contributions you would

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Posted in COAT, Oligoinformatics, Progress update, Research

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