Transcriptome-wide dinucleotide frequencies are conserved between mouse and man

We have calculated the average dinucleotide frequencies in 5’UTR-, coding sequence (CDS)-, and 3’UTR regions across

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the entire transcriptome of both mouse and human. As seen in the figure below (dark grey bars: 5’UTR, grey: CDS, light grey: 3’UTR), for most dinucleotides, the frequency is specific for a given region of a transcript. Taking the dinucleotide AA as an example, in both mice and humans, it has the lowest frequency in the 5ÚTR, and the highest in the 3’UTR.



p>Notice that the frequency differences seem to be the same between human (upper panel) and mouse (lower panel). We plot this directly in the

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figure below and see that generic viagra online indeed, for each region, the frequencies

between does cialis work better than viagra mouse and man match quite closely (the correlation pharmacy online is r>0.98 for both 5’UTR, CDS, and 3’UTR).

This conservation indicates that the differences in dinucleotide frequencies between regions are important.

Probably, these observations have already been explained in some great paper we just do not know about. Please drop us a line if you know of such a paper.


Posted in Oligoinformatics

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