OTS day 1: new RNAi triggers

The Oligonucleotide Therapeutic Society annual meeting has started. Taking place in the architectural pleasing Royal Library in Copenhagen.

I will try to online cialis report on my subjective picking of highlights from this conference. I will be blogging from my ipad, but will be updating some of the posts later with pictures links etc.

The most interesting session of the generic viagra first day was the ‘hot topics’ selcted from the submitted abstracts.

Two alternative ways to trigger RNAi was presented – interesting both scientifically and for their business perspectives, since they most likely fall outside of Alnylams IP-dominance in the RNAi field.

Dong-ki Lee, presented to me new, but at least partially published data on alternative structures to the canonical Tuschl type siRNA. Lee’s group demonstrated that assymmetric viagra when to take duplexes in which the passenger strand was truncated was in some cases superior to standard siRNA. LNA modifications increased potency.

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p>Eric Swayze, from ISIS, thourough medicinal chemistry work, showing that ssRNA,

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with various modifications, especially 2’F, cause ago2 dependent knockdown of target mRNAs. In vivo

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they reached the same ED50 as standard MOE-gapmers.

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